Part:BBa_K364306
Human CAR LBD
The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene.CAR is a member of the nuclear receptor superfamily and along with PXR functions as a sensor of endobiotic and xenobiotic substances and in response upregulates the expression of proteins responsible for the metabolism and excretion of these substances. Hence CAR (and PXR) are important in the detoxification of foreign substances such as drugs.
More on CAR here: [http://en.wikipedia.org/wiki/Constitutive_androstane_receptor].
CAR Uniprot: [http://www.uniprot.org/uniprot/Q14994].
View the murine CAR lingand binding domain crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1XNX&bionumber=1].
Description of the murine CAR LBD crystal structure with reference here: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727924/?tool=pubmed].
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 113
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
n/a | Human CAR LBD |